Lupus Drug Actions and Side Effects

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Immunosuppressives Treat inflammation with kidney or central nervous system involvement  
cyclophosphamide (Cytoxan) Diarrhea,dizziness, fatigue, fever, anaphylaxis, Nausea, vomiting,  anemia, weight gain or loss, Alopecia, dermatiis and nephrotoxicity.
mycophenolate mofetil (CellCept) Birth Defects, Increased risk for Infection, Increased risk for Cancer, Low Blood cell counts, Stomach problems, Diarrhea, vomiting, pain, Stomach area pain and High Blood presure
Corticosteroids Treats Inflammation Suppression  
prednisone (Deltasone) Muscle wasting, headache,  confusion, psychosis, edema, insomnia, nausea, vomiting, peptic ulcer, muscle weakness,  osteoporosis and hyperglycemia
hydrocortisone depression,malaise, obesity, peptic ulcer, urinary frequency and urgency,weight gain, headache, mental disturbances, insomnia,anxiety,  palpitations, fluid retention, cramping, bleeding, nausea, increased appetite, osteoporosis, muscle wasting, skin atrophy (more)
Monoclonal Approved for rheumatoid arthritis.  Shows promise for Lupus, soon to be approved by FDA  
rituximab (Rituxan) Fatigue, night sweats, chills, fever, headache, dizziness, depression, hypotension, peripheral edema, nausea, voimiting, abdominal pain, anemia, rhinitis, chest pain, hypotension and hypertension
Antimalarials: Flare prevention.  Treatment of fatigue joint pain and skin rashes  
hydroxychloroquine (Plaquenil) Fatigue, headache, hair loss, mental changes, anxiety, blurred vision, anorexia, nausea, vomiting, diarrhea, vertigo, abdominal cramps, weight loss, rash and itching.
chloroquine (Aralen) Night blindness, vomiting, hypotension, diarrhea, abdominal cramps, nausea, confusion, anorexia, fatigue, irritability, muscle weakness, reflex changes, bertigo, alopecia and blurred vision 
methotrexate   Confusion, headache, drowsiness, tremors, blurred vision, fetal defects, dizziness, convulsions,  coma, pharyngitis, nausea, vomiting, diarrhea, infertility, anemia, photosensitivity, alopecia, malaise, chills, and fever 
NSAIDs Treats joint or chest pain or fever  
propoxyphene (Darvon) Tremor, headache, dizziness, drowsiness, sedation, fatigue, coma, convulsions, restlessness, confusion, toxic psychosis, nausea, vomiting, abdominal pain, constipation, diabetes insipidus and pulminary edema.
tramadol (Ultram) Dizziness, drowsiness, vertigo, seizures, palpitations, fatigue, headache, restlessness, confusion, anaphylactic reaction, anxiety, sleep disturbances,  nausea, constipation, vomiting, diarrhea, abdominal pain, sweating,  rash and visual disturbances


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Source: FDA